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Synthesis, Antimalarial Activity, and Docking Studies of Monocarbonyl Analogues of Curcumin

Authors
  • Yusuf, Amina S.
  • Sada, Ibrahim
  • Hassan, Yusuf
  • Olomola, Temitope O.
  • Adeyemi, Christiana M.
  • Ajibade, Sunday O.
Type
Published Article
Journal
Ovidius University Annals of Chemistry
Publisher
Sciendo
Publication Date
Oct 01, 2018
Volume
29
Issue
2
Pages
92–96
Identifiers
DOI: 10.2478/auoc-2018-0013
Source
De Gruyter
Keywords
License
Green

Abstract

The synthesis of five monocarbonyl analogues of curcumin is described. In vitro anti-malarial assay of the compounds was carried out and the effect of the substituents on the aryl ring has been described. The results show that all the five compounds exhibited some reasonable activity against the chloroquine-resistant plasmodium parasite. Molecular docking studies further confirmed the observed biological activity of the compounds.

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