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Synthesis and antibacterial activity of 3-(2-arylvinylen)-2-isoxazolines.

Authors
  • Vittorio, F
  • Ronsisvalle, G
  • Pappalardo, M S
  • Blandino, G
Type
Published Article
Journal
Il Farmaco; edizione scientifica
Publication Date
May 01, 1985
Volume
40
Issue
5
Pages
359–368
Identifiers
PMID: 3891404
Source
Medline
License
Unknown

Abstract

3-[2-(5-Nitro-2-furyl)vinylen]-2-isoxazoline (VIII) and 3-nitro-, 3-amino- and 3-acylaminostyryl-2-isoxazolines have been synthesized and tested for antibacterial activity. Compound (VIII) showed potent antibacterial activity in vitro against several strains of S. aureus and E. coli (two to eight times more active than furazolidone). None of the styryl derivatives exhibited significant activity.

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