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Synthesis and antiallergy activity of 4-oxopyrano[3,2-b]indoles.

Authors
  • Unangst, P C
  • Brown, R E
  • Herzig, D J
Type
Published Article
Journal
Journal of medicinal chemistry
Publication Date
Nov 01, 1980
Volume
23
Issue
11
Pages
1251–1255
Identifiers
PMID: 7452677
Source
Medline
License
Unknown

Abstract

A series of 4-oxopyrano[3,2-b]indole carboxylic acids, tetrazoles, and carboxamidotetrazoles has been prepared and tested for antiallergy potential in the rat passive cutaneous anaphylaxis (PCA) assay. Many of the compounds showed activity comparable or superior to that of cromolyn sodium or doxantrazole. Several compounds were orally active.

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