Affordable Access

Access to the full text

Synthesis andin vitro cytotoxicity of cinnamaldehydes to human solid tumor cells

Authors
  • Kwon, Byoung-Mog1
  • Lee, Seung-Ho1
  • Choi, Sang Un2
  • Park, Sung Hee2
  • Lee, Chong Ock2
  • Cho, Young-Kwon3
  • Sung, Nack-Do3
  • Bok, Song-Hae1
  • 1 Protein Regulator RU, Korea Research Institute of Bioscience & Biotechnology, Taejon, 305-600, Korea , Taejon
  • 2 Korea Research Institute of Chemical Technology, Pharmaceutical Screening Lab., Taejon, 305-606, Korea , Taejon
  • 3 Choongnam National University, Department of Agricultural Chemistry, Taejon, 305-606, Korea , Taejon
Type
Published Article
Journal
Archives of Pharmacal Research
Publisher
Springer-Verlag
Publication Date
Apr 01, 1998
Volume
21
Issue
2
Pages
147–152
Identifiers
DOI: 10.1007/BF02974019
Source
Springer Nature
Keywords
License
Yellow

Abstract

Cinnamaldehydes and related compounds were synthesized from various cinnamic acids based on the 2′-hydroxycinnamaldehyde isolated from the bark ofCinnamomum cassia Blume. The cytotoxicity to human solid tumor cells such as A549, SK-OV-3, SK-MEL-2, XF498 and HCT15 were measured. Cinnamic acid, cinnamates and cinnamyl alcohols did not show any cytotoxicity against the human tumor cells. Cinnamaldehydes and realted compounds were resistant to A549 cell line up to 15 μg/ml. In contrast, HCT15 and SK-MEL-2 cells were much sensitive to these cinnamaldehyde analogues which showed ED50 values 0.63-8.1 μg/ml. Cytotoxicity of the saturated aldehydes was much weak compared to their unsaturated aldehydes. From these studies, it was found that the key functional group of the cinnamaldehyde-related compounds in the antitumor activity is the propenal group.

Report this publication

Statistics

Seen <100 times