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Synthesis of aminomethyl derivatives of 4-phenyl-1,2,4-triazolin-5-one-1-acetic acid amide and 3,4-diphenyl-1,2,4-triazolin-5-one-1-acetic acid amide.

Authors
  • Dobosz, M
  • Struga, M
Type
Published Article
Journal
Acta poloniae pharmaceutica
Publication Date
Jan 01, 2000
Volume
57
Issue
2
Pages
123–127
Identifiers
PMID: 10934791
Source
Medline
License
Unknown

Abstract

Ehtyl esters of 4-phenyl-1,2,4-triazolin-5-one-1-acetic acid and 3,4-diphenyl-1,2,4-triazolin-5-one-1-acetic acid were transformed into the corresponding amides [Ia, b]. The aminomethylation reactions afforded Mannich bases [IIa, b-VIa, b] exhibiting the expected pharmacological effects.

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