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Synthesis and acylation of myelin proteolipid protein in quaking mouse brain.

Authors
Type
Published Article
Journal
Metabolic brain disease
Publication Date
Volume
1
Issue
4
Pages
241–247
Identifiers
PMID: 3508244
Source
Medline

Abstract

The synthesis and acylation of proteolipid proteins where investigated in tissue slices prepared from 19-day-old quaking and normal littermate mouse brain. The mutant CNS had a normal rate of total protein synthesis but synthesis of the myelin-specific proteins, proteolipid protein (PLP) and intermediate protein (IP), was impaired to approximately 50% of control. The acylation of myelin proteins with labeled palmitate was reduced to only about 20% of control. The acylation of two nonmyelin proteolipid proteins was also significantly reduced. The incorporation of palmitate into phospholipids was identical in control and mutant. The results indicate impaired synthesis of PLP and IP and a general deficit in protein acylation in quaking brain.

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