Affordable Access

Synthesis of [8-norleucine]somatostatin-28.

Authors
  • Moroder, L
  • Wünsch, E
  • Vaysse, N
  • Ribet, A
Type
Published Article
Journal
Hoppe-Seyler's Zeitschrift fur physiologische Chemie
Publication Date
Oct 01, 1982
Volume
363
Issue
10
Pages
1247–1251
Identifiers
PMID: 6183184
Source
Medline
Language
English
License
Unknown

Abstract

Because of the high tendency of natural and synthetic somatostatin-28 to S-oxide formation at methionine-8 via air-oxidation, the 8-norleucine analogue was prepared following the synthetic route previously elaborated for the parent methionine peptide. [Nle8]-somatostatin-28 was obtained at a high degree of purity as judged by different analytical assays. It was found to possess the identical stimulatory effect on amylase release from pancreatic acini as the natural peptide extracted from porcine intestine.

Report this publication

Statistics

Seen <100 times