The synthesis of various 6-substituted-4-hydroxy-2-pyridinones is reported. The functionalized keto-dioxinones were constructed via a diethylzinc mediated crossed Claisen condensation reaction and subsequent enamine formation, thermolysis, and cyclization-aromatization providing the pyridinone unit.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/21879703