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Synthesis of 3- amino-thiochromanes from 4- benzyl 2-thiazolines, via an unprecedented intramolecular electrophilic aromatic substitution

Authors
  • Mercey, Guillaume
  • Legay, Rémi
  • Lohier, Jean-François
  • Sopkova-De Oliveira Santos, Jana
  • Levillain, Jocelyne
  • Gaumont, Annie-Claude
  • Gulea, Mihaela
Publication Date
Apr 22, 2010
Source
HAL-UPMC
Keywords
Language
English
License
Unknown
External links

Abstract

A one-pot synthesis of various N-substituted 3-amino-thiochromanes from 4-benzyl-2-methyl thiazoline is described. The reaction involves the formation of a disulfide, which subsequently takes part in an unprecedented intramolecular electrophilic aromatic substitution.

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