Affordable Access

A synthesis of 3',4'-dideoxykanamycin B.

Authors
  • Miyake, T
  • Tsuchiya, T
  • Umezawa, S
  • Umezawa, H
Type
Published Article
Journal
Carbohydrate Research
Publisher
Elsevier
Publication Date
Jul 01, 1976
Volume
49
Pages
141–151
Identifiers
PMID: 963688
Source
Medline
License
Unknown

Abstract

3',4',-Dideoxykanamycin B, the kanamycin B derivative that is active against resistant bacteria, was prepared from kanamycin B via N-tosylation, 3',4'-O-sulphonylation, 3',4'-unsaturation, and hydrogenation. The unsaturated intermediate was obtained from the 3',4'-di-O-sulphonyl derivatives by the action of sodium iodide in N,N-dimethylformamide; if zinc dust was added in this reaction, aziridine derivatives were formed. Removal of the tosyl group was successfully performed by using sodium in ammonia-ethylamine.

Report this publication

Statistics

Seen <100 times