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Synthesis of 2,6'-dioxo-1',5',6',7'-tetrahydrospiro[indoline-3,4'-pyrazolo[3,4-b]pyridine]-5'-carbonitriles via a one-pot, three-component reaction in water.

Authors
  • Rahmati, Abbas
  • Kenarkoohi, Tahmineh
  • Khavasi, Hamid Reza
Type
Published Article
Journal
ACS Combinatorial Science
Publisher
American Chemical Society
Publication Date
Dec 10, 2012
Volume
14
Issue
12
Pages
657–664
Identifiers
DOI: 10.1021/co300047j
PMID: 23190397
Source
Medline
License
Unknown

Abstract

A one-pot, three-component condensation reaction of an isatin, aminopyrazole, and alkyl cyanoacetate in water to give 2,6'-dioxo-1',5',6',7'-tetrahydrospiro[indoline-3,4'-pyrazolo[3,4-b]pyridine]-5'-carbonitrile with good yields, at 90 °C, using a Et(3)N as catalyst, is described.

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