The synthesis of 191Pt labelled JM216, an orally active platinum anti-tumour agent.
- Published Article
Applied Radiation and Isotopes
- Publication Date
Apr 01, 1997
The orally active platinum anti-tumour complex JM216[bis-acetatoamminedichlorocyclohexylamineplatinum(IV)] is at present in stage II clinical trials. A procedure for synthesising the complex labelled with 191Pt or 188Pt at the platinum centre has been developed. The purity (shown by HPLC) is 98% and the specific activity (0.3-0.4 Ci/kg) is enough for in vivo and in vitro studies.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/9106988