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A Synonymous Mutation at Bovine Alpha Vitronectin Domain of Integrin Host Receptor (ITGAV) Gene Effect the Susceptibility of Foot-and-Mouth Disease in Crossbred Cattle.

Authors
  • Singh, Rani1
  • Alex, Rani1
  • Singh, Umesh1
  • Kumar, Sushil1
  • Sengar, Gyanendra Singh1
  • Raja, T V1
  • Alyethodi, R R1
  • Kumar, Ashish1
  • Deb, Rajib2
  • 1 Molecular Genetics Laboratory, ICAR-Central Institute for Research on Cattle, Meerut, 250 001, Uttar Pradesh, India. , (India)
  • 2 Molecular Genetics Laboratory, ICAR-Central Institute for Research on Cattle, Meerut, 250 001, Uttar Pradesh, India. [email protected] , (India)
Type
Published Article
Journal
Advances in experimental medicine and biology
Publication Date
Jun 01, 2017
Identifiers
DOI: 10.1007/5584_2017_47
PMID: 28567614
Source
Medline
Keywords
License
Unknown

Abstract

Integrins are one of the major biologically active proteins responsible for Foot-and-mouth disease virus (FMDV)- host interaction. Out of various heterodimeric integrins discovered, αVβ6 heterodimer serves as the chief receptor for FMDV host tropism. Earlier studies reported that, SNPs at beta 6 subunit (ITGB6) were associated with the occurrence of the diseases in cattle. In this study we report the association between a synonymous SNP (rs719257875) at bovine alpha vitronectin domain of integrin receptor (ITGAV) gene and FMD susceptibility in cattle. A strong significant association (P < 0.0001) of the genotypes with FMD susceptibility were obtained, where the CC genotypes play a major role in occurrence of FMD in crossbred cattle.

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