Affordable Access

Access to the full text

Synergy and Interactions Among Biological Pathways Leading to Preterm Premature Rupture of Membranes

Authors
  • Lannon, Sophia M. R.1
  • Vanderhoeven, Jeroen P.2
  • Eschenbach, David A.1
  • Gravett, Michael G.1, 3
  • Adams Waldorf, Kristina M.1
  • 1 University of Washington, 1959 NE Pacific St, Seattle, WA, USA , Seattle (United States)
  • 2 Swedish Medical Center, Seattle, WA, USA , Seattle (United States)
  • 3 Global Alliance to Prevent Prematurity & Stillbirth, Seattle, WA, USA , Seattle (United States)
Type
Published Article
Journal
Reproductive Sciences
Publisher
SAGE Publications
Publication Date
Oct 01, 2014
Volume
21
Issue
10
Pages
1215–1227
Identifiers
DOI: 10.1177/1933719114534535
Source
Springer Nature
Keywords
License
Yellow

Abstract

Preterm premature rupture of membranes (PPROM) occurs in 1% to 2% of births. Impact of PPROM is greatest in low- and middle-income countries where prematurity-related deaths are most common. Recent investigations identify cytokine and matrix metalloproteinase activation, oxidative stress, and apoptosis as primary pathways to PPROM. These biological processes are initiated by heterogeneous etiologies including infection/inflammation, placental bleeding, uterine overdistention, and genetic polymorphisms. We hypothesize that pathways to PPROM overlap and act synergistically to weaken membranes. We focus our discussion on membrane composition and strength, pathways linking risk factors to membrane weakening, and future research directions to reduce the global burden of PPROM.

Report this publication

Statistics

Seen <100 times