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Synergistic interactions of the antiretroviral protease inhibitors saquinavir and ritonavir with chloroquine and mefloquine against Plasmodium falciparum in vitro.

Authors
  • Skinner-Adams, T S
  • Andrews, K T
  • Melville, L
  • McCarthy, J
  • Gardiner, D L
Type
Published Article
Journal
Antimicrobial agents and chemotherapy
Publication Date
Feb 01, 2007
Volume
51
Issue
2
Pages
759–762
Identifiers
PMID: 17088482
Source
Medline
License
Unknown

Abstract

The antimalarial activity of several antiretroviral protease inhibitor combinations was investigated. Data demonstrate that ritonavir and saquinavir behave synergistically with chloroquine and mefloquine. These data, and interactions with pepstatin-A, E-64, and bestatin, suggest that human immunodeficiency virus protease inhibitors do not target digestive-vacuole plasmepsins.

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