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Synergistic effect of combined hyperthermia and a nitrosourea in treatment of a murine ependymoblastoma.

Authors
  • Thuning, C A
  • Bakir, N A
  • Warren, J
Type
Published Article
Journal
Cancer research
Publication Date
Aug 01, 1980
Volume
40
Issue
8 Pt 1
Pages
2726–2729
Identifiers
PMID: 7388821
Source
Medline
License
Unknown

Abstract

The effectiveness of heat therapy in combination with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea on a murine ependymoblastoma was investigated. Based on survival time and the number of survivors, whole-body hyperthermia (40 degrees) increased the therapeutic effectiveness of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea. Heat alone did not modify the course of the tumor. Microscopic evidence of accelerated tumor destruction in hyperthermic mice was apparent within 24 hr of drug administration. A temporary drop in animal weight was observed with hyperthermia at the higher dose levels of drug. Mechanisms which may be involved in this synergism are discussed.

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