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Synergistic Effect of Ceftazidime-Avibactam with Meropenem against Panresistant, Carbapenemase-Harboring Acinetobacter baumannii and Serratia marcescens Investigated Using Time-Kill and Disk Approximation Assays

Authors
  • Gaudereto, Juliana Januário
  • Perdigão Neto, Lauro Vieira
  • Leite, Gleice Cristina
  • Ruedas Martins, Roberta
  • Boas do Prado, Gladys Villas
  • Rossi, Flavia
  • Guimarães, Thais
  • Levin, Anna Sara
  • Costa, Silvia Figueiredo
Type
Published Article
Journal
Antimicrobial Agents and Chemotherapy
Publisher
American Society for Microbiology
Publication Date
Apr 25, 2019
Volume
63
Issue
5
Identifiers
DOI: 10.1128/AAC.02367-18
PMID: 30783003
PMCID: PMC6496051
Source
PubMed Central
Keywords
License
Unknown

Abstract

Susceptibility of ceftazidime-avibactam and in vitro synergy with meropenem were investigated using disk approximation and time-kill assays against 11 multiresistant Acinetobacter baumannii isolates harboring oxacillinases and 5 Serratia marcescens isolates carrying bla KPC-2. Ceftazidime-avibactam was very active and synergistic with meropenem against multiresistant S. marcescens isolates. On the other hand, only the A. baumannii isolates coharboring bla OXA-23 and bla OXA-117 displayed synergy. The disk approximation technique presented good sensitivity for synergism in S. marcescens infection.

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