Affordable Access

deepdyve-link
Publisher Website

Synergistic antitumor effect of β-elemene and etoposide is mediated via induction of cell apoptosis and cell cycle arrest in non-small cell lung carcinoma cells.

Authors
  • Zhang, Fan
  • Xu, Ling
  • Qu, Xiujuan
  • Zhao, Mingfang
  • Jin, Bo
  • Kang, Jian
  • Liu, Yunpeng
  • Hu, Xuejun
Type
Published Article
Journal
Molecular Medicine Reports
Publisher
Spandidos Publications
Publication Date
Jan 01, 2011
Volume
4
Issue
6
Pages
1189–1193
Identifiers
DOI: 10.3892/mmr.2011.537
PMID: 21904777
Source
Medline
License
Unknown

Abstract

β-Elemene, an anticancer agent, was isolated from the traditional Chinese medicine plant, curcuma aromatica. In this study, we investigated the synergistic antitumor effect of β-elemene and etoposide phosphate (VP-16) in A549 non-small cell lung carcinoma cells. The cells were treated with β-elemene (20 or 50 µg/ml), VP-16 (15 µg/ml) or the combination of both for 24 h. Compared to the treatment with β-elemene or VP-16 alone, an increased antitumor activity was observed with the combination of both, which was mediated by the cleavage of PARP, the up-regulation of Bax, p53 and p21, and the suppression of cyclin D1. These results suggest that the combination of β-elemene and VP-16 may be a promising therapeutic option for lung cancer.

Report this publication

Statistics

Seen <100 times