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Synergism of PDL/PD1 and IL33/ST2 Axis in Tumor Immunology

Authors
  • Jovanovic, Marina
  • Gajovic, Nevena
  • Lukic, Miodrag L.
  • Popovic, Ana
  • Jovanovic, Ivan
Type
Published Article
Journal
Serbian Journal of Experimental and Clinical Research
Publisher
Sciendo
Publication Date
Sep 01, 2019
Volume
20
Issue
3
Pages
223–228
Identifiers
DOI: 10.2478/sjecr-2018-0033
Source
De Gruyter
Keywords
License
Green

Abstract

When it comes to tumor immunology, understanding of molecular pathways is rather important. During oncogenesis, many molecules should be taken in consideration altogether in context of a single malignancy. It is of a great significance to determine whether these molecules act synergistically or contrary, whether to understand a malignant disease more thoroughly, or even more important, to reveal new approaches of therapy. In this review, we discuss whether and how IL-33/ST2 and PD-1/PDL axis involve in antitumor immunity.

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