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Synaptic targeting of glutamate receptors.

Authors
  • Ehlers, M D
  • Mammen, A L
  • Lau, L F
  • Huganir, R L
Type
Published Article
Journal
Current Opinion in Cell Biology
Publisher
Elsevier
Publication Date
Aug 01, 1996
Volume
8
Issue
4
Pages
484–489
Identifiers
PMID: 8791455
Source
Medline
License
Unknown

Abstract

The proper targeting and clustering of neurotransmitter receptors at appropriate postsynaptic sites are principal requirements for the formation of functional synapses. Recently, new studies have begun to elucidate the mechanisms underlying the targeting and clustering of glutamate receptors at excitatory synapses in the brain. Members of the SAP90/PSD-95 family of proteins have emerged as potential regulators of glutamate-receptor membrane distribution. Further, targeting motifs within glutamate receptor subunits have been identified. These findings provide important clues in the effort to understand the molecular features of synaptic organization.

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