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Synaptic localisation of agmatinase in rat cerebral cortex revealed by virtual pre-embedding.

Authors
  • Madai, V I
  • Poller, W C
  • Peters, D
  • Berger, J
  • Paliege, K
  • Bernard, R
  • Veh, R W
  • Laube, G
Type
Published Article
Journal
Amino Acids
Publisher
Springer-Verlag
Publication Date
Sep 01, 2012
Volume
43
Issue
3
Pages
1399–1403
Identifiers
DOI: 10.1007/s00726-011-1195-5
PMID: 22160263
Source
Medline
License
Unknown

Abstract

Light microscopic evidence suggested a synaptic role for agmatinase, an enzyme capable of inactivating the putative neurotransmitter and endogenous anti-depressant agmatine. Using electron microscopy and an alternative pre-embedding approach referred to as virtual pre-embedding, agmatinase was localised pre- and postsynaptically, to dendritic spines, spine and non-spine terminals, and dendritic profiles. In dendritic spines, labelling displayed a tendency towards the postsynaptic density. These results further strengthen a synaptic role for agmatine and strongly suggest a regulatory role for synaptically expressed agmatinase.

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