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Symptom and health-related quality-of-life measures for use in selected gastrointestinal disease studies: a review and synthesis of the literature.

Authors
  • Rentz, A M
  • Battista, C
  • Trudeau, E
  • Jones, R
  • Robinson, P
  • Sloan, S
  • Mathur, S
  • Frank, L
  • Revicki, D A
Type
Published Article
Journal
PharmacoEconomics
Publication Date
Jan 01, 2001
Volume
19
Issue
4
Pages
349–363
Identifiers
PMID: 11383752
Source
Medline
License
Unknown

Abstract

Patient-rated symptom and health-related quality-of-life (HR-QOL) outcomes are important end-points for clinical trials of medical treatments for gastrointestinal (GI) disorders. Based on this review, patient outcomes research is focused on gastroesophageal reflux disease and dyspepsia, with a growing interest in irritable bowel syndrome but little research in gastroparesis. State-of-the-art for patient-rated symptom scales is rudimentary with an abundance of scales and little attention to systematic instrument development or comprehensive psychometric evaluation. Generally, disease-specific HR-QOL measures have been more systematically developed and evaluated psychometrically, but few have been incorporated into clinical trials. More comprehensive outcome assessments are needed to determine the effectiveness of new medical treatments for functional GI disorders. Future clinical trials of GI disorders should combine clinician assessments of outcomes and symptoms with patient-rated symptom and HR-QOL end-points.

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