Affordable Access

deepdyve-link
Publisher Website

Symptom clusters in patients with breast cancer receiving radiation therapy.

Authors
  • Chow, Selina1
  • Wan, Bo Angela1
  • Pidduck, William1
  • Zhang, Liying1
  • DeAngelis, Carlo1
  • Chan, Stephanie1
  • Yee, Caitlin1
  • Drost, Leah1
  • Leung, Eric1
  • Sousa, Philomena1
  • Lewis, Donna1
  • Lam, Henry1
  • Chow, Ronald2
  • Lock, Michael2
  • Chow, Edward3
  • 1 Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada. , (Canada)
  • 2 London Regional Cancer Program, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada. , (Canada)
  • 3 Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada. Electronic address: [email protected] , (Canada)
Type
Published Article
Journal
European journal of oncology nursing : the official journal of European Oncology Nursing Society
Publication Date
Jul 10, 2019
Volume
42
Pages
14–20
Identifiers
DOI: 10.1016/j.ejon.2019.07.004
PMID: 31446259
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Symptoms experienced by breast cancer patients often cluster together in groups known as "symptom clusters". The aim was to determine the symptom clusters in women with non-metastatic breast cancer treated by radiation therapy (RT). Edmonton Symptom Assessment Scale (ESAS) scores were taken from breast cancer patients receiving RT before, at completion of RT, and after RT. Exploratory factor analysis (EFA), principal component analysis (PCA), and hierarchical cluster analysis (HCA) were used to identify symptom clusters among the nine ESAS items at all three time points. This study included 1224 patients. The PCA and EFA identified the same two symptom clusters before the start of RT: 1) pain, tiredness, nausea, drowsiness, appetite, and dyspnea; 2) depression, anxiety, and wellbeing. The HCA further split the symptoms into three clusters. Wellbeing, depression, and anxiety consistently clustered together. Among the ESAS scores collected at the end of and after RT, each statistical method identified different symptom clusters. For the symptom clusters experienced at the end of RT, the following symptoms were always in the same cluster: wellbeing, depression, and anxiety; nausea and appetite; drowsiness and dyspnea. Following RT, depression and anxiety consistently clustered together, with nausea and appetite in a second cluster. Among the symptom clusters derived before, at the end of RT, and after RT, the following symptoms consistently presented together: depression and anxiety, nausea and appetite, pain and tiredness, and drowsiness, dyspnea, and tiredness. Understanding symptom clusters in this population can improve management of symptoms. Copyright © 2019 Elsevier Ltd. All rights reserved.

Report this publication

Statistics

Seen <100 times