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Sympathetic activation: a potential link between comorbidities and COVID‐19

Authors
  • Porzionato, Andrea1
  • Emmi, Aron1
  • Barbon, Silvia1
  • Boscolo‐Berto, Rafael1
  • Stecco, Carla1
  • Stocco, Elena1
  • Macchi, Veronica1
  • De Caro, Raffaele1
  • 1 University of Padova, Italy , (Italy)
Type
Published Article
Journal
FEBS Journal
Publisher
Wiley (Blackwell Publishing)
Publication Date
Aug 01, 2020
Identifiers
DOI: 10.1111/febs.15481
PMID: 32779891
PMCID: PMC7405290
Source
PubMed Central
Keywords
License
Unknown
External links

Abstract

Aging and comorbidities (lung, cardiovascular, kidney, and metabolic diseases) are characterized by sympathetic overactivity, which may exert detrimental effects on lungs, heart, vessels, kidney, metabolism, and/or immune system of coronavirus disease 2019 (COVID‐19) patients. COVID‐19 may furtherly increase sympathetic discharge, through hypoxia, angiotensin‐converting enzyme (ACE)1/ACE2 imbalance, immune/inflammatory factors, and emotional distress. Thus, sympathetic activation could represent a so‐far undervalued mechanism for a vicious circle between COVID‐19 and comorbidities.

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