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SWR mice are resistant to collagen-induced arthritis but produce potentially arthritogenic antibodies.

Authors
Type
Published Article
Journal
Arthritis & Rheumatism
Publisher
Wiley (John Wiley & Sons)
Volume
34
Issue
6
Pages
776–781
Source
UCSC Stem Cell biomedical-ucsc
License
Unknown

Abstract

SWR mice are resistant to collagen-induced arthritis but produce antibodies to type II collagen. To determine if these antibodies have arthritogenic potential, serum from collagen-immunized mice was concentrated and passively transferred to DBA/1 mice. The recipients developed severe arthritis within 72 hours. To evaluate the role of complement, SWR mice were bred with congenic inbred B10.D2/oSn (complement deficient) and B10.D2/nSn (complement normal) mice. Collagen-immunized (SWR x B10.D2/nSn)F1 mice had high levels of C5 and were susceptible to arthritis, while (SWR x B10.D2/oSn)F1 mice were deficient in C5 and were resistant to arthritis.

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