In this study, we synthesized a random poly[( N -isopropylacrylamide)- co -(2-hydroxyethylmethacrylate)- co -( N -methylolacrylamide)] [poly(NIPAAm- co -HEMA- co -NMA)] copolymer through free-radical polymerization. The NIPAAm, HEMA and NMA moieties were framed to provide thermoresponsiveness, water absorption and retention control, and chemical cross-linking to achieve stability in aqueous medium, respectively. The copolymer showed a significant change in optical transmittance with a variation in temperature due to the change in volume (i.e., hydrophilic/hydrophobic) between 25 °C and 40 °C, attributed to the lower critical solution temperature property of the NIPAAm moiety. The copolymers were wire-bar-coated onto polyethylene terephthalate (PET) fabric. Variation in the water contact angle affirmed the switchable wettability due to the change in temperature. We tested the coated fabrics for moisture absorption and release at different temperatures. The results at 20 °C and 37 °C indicated that the P2 copolymer had the highest moisture absorption and release capability. Therefore, the copolymers with tailored properties can be used as smart textiles for activity specific clothing.