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Sustained-release hydrogels of ivermectin as alternative systems to improve the treatment of cutaneous leishmaniasis.

Authors
  • Romero, Analía I1, 2
  • Cid, Alicia G1, 2
  • Minetti, Nicolás E1, 2
  • Briones Nieva, Cintia A1, 2
  • García Bustos, María F3
  • Gonzo, Elio E1, 2
  • Villegas, Mercedes1, 2
  • M Bermúdez, José1, 2
  • 1 Instituto de Investigaciones para la Industria Química, Universidad Nacional de Salta - Consejo Nacional de Investigaciones Científicas y Técnicas, Salta, Argentina. , (Argentina)
  • 2 Facultad de Ingeniería, Universidad Nacional de Salta, Salta, Argentina. , (Argentina)
  • 3 Instituto de Patología Experimental, Universidad Nacional de Salta - Consejo Nacional de Investigaciones Científicas y Técnicas, Salta, Argentina. , (Argentina)
Type
Published Article
Journal
Therapeutic Delivery
Publisher
"Future Science, LTD"
Publication Date
Dec 01, 2020
Volume
11
Issue
12
Pages
779–790
Identifiers
DOI: 10.4155/tde-2020-0090
PMID: 33198601
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Background: Leishmaniasis is a neglected tropical disease and its cutaneous form manifests as ulcers or nodules, generally in exposed parts of the body. This work aimed to develop ivermectin (IVM) thermosensitive hydrogels as topical formulations to improve cutaneous leishmaniasis treatment. Materials & methods: Hydrogels based on poloxamers 407 and 188 with different concentrations of IVM were prepared and rheologically characterized. The IVM release profiles were obtained and mathematically analyzed using the Lumped model. Results: The formulation containing 1.5% w/w of IVM presented an adequate gelling temperature, an optimal complex viscosity and elastic modulus. Hydrogels allowed to modulate the release of IVM. Conclusion: IVM thermosensitive hydrogels can be considered a valuable alternative to improve the treatment of cutaneous leishmaniasis.

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