Affordable Access

Sustainable Transformations of Methyl Coumalate : efficient Preparations of Unsaturated Carboxylic Acids, 2HPyrans, Trifluoromethyl Benzenes and Fluorescents Molecules

Authors
  • Chang, Liang
Publication Date
Jul 19, 2018
Source
HAL-Descartes
Keywords
Language
English
License
Unknown
External links

Abstract

In this work, we have described the development of new transformations using bio-based renewable methyl coumalate as feedstock. An iron and copper catalyzed one-pot sequential double alkyl-alkyl or alkyl-hydride 1,6-addition with methyl coumalate was described. We then described an efficient synthesis of tetrasubstituted 2H-pyrans under mild condition. Later we reported a solvent-free reaction of methyl coumalate with trifluoromethyl-β-diketones, in a tBuOK-catalyzed domino sequence. A novel reaction, for efficient C-C bond formation between the bio-based methyl coumalate and a variety of imines and aldehydes via MBH pathway was reported. Finally, we reported a novel, general dearomatization strategy with an unprecedented pyrido[1, 2-a] fused heterocyclic scope.

Report this publication

Statistics

Seen <100 times