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Susceptibility and interactions between Aedes mosquitoes and Zika viruses.

Authors
  • Zhou, Teng-Fei1
  • Lai, Ze-Tian1
  • Liu, Shuang1
  • Zhou, Jia-Yong1
  • Liu, Yang2
  • Wu, Yang1
  • Xu, Ye1
  • Wu, Kun1
  • Gu, Jin-Bao1
  • Cheng, Gong3
  • Chen, Xiao-Guang1
  • 1 Department of Pathogen Biology, Key Laboratory of Tropical Disease Research of Guangdong Province, School of Public Health, Southern Medical University, Guangzhou, China. , (China)
  • 2 Department of Biochemistry & Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA.
  • 3 Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China. , (China)
Type
Published Article
Journal
Insect Science
Publisher
Wiley (Blackwell Publishing)
Publication Date
Oct 01, 2021
Volume
28
Issue
5
Pages
1439–1451
Identifiers
DOI: 10.1111/1744-7917.12858
PMID: 32725867
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Zika virus disease is caused by Zika virus infection, as transmitted by Aedes spp. mosquitoes. Many of the Zika virus strains isolated from patients display different pathogenicities toward humans. The vector mosquitoes for Zika virus are mainly of the Aedes genus, especially Aedes aegypti and Aedes albopictus. However, susceptibility and interactions between Aedes spp. mosquitoes and Zika viruses remain unclear. In this study, we chose two Zika virus strains (FSS13025 and PRVABC59) with different abilities to infect the primary vector mosquitoes Ae. aegypti and Ae. albopictus. The transcriptomes and small RNA profiles of infected and uninfected mosquitoes were comparatively analyzed, and differentially expressed genes were functionally examined using RNA interference. According to the results, the susceptibility of PRVABC59 was higher than that of FSS13025 in Aedes vector mosquitoes, and Ae. aegypti was more susceptible to Zika virus than was Ae. albopictus. For PRVABC59 infection, specific differential expression profiles correlated with Ae. aegypti and Ae. albopictus, and susceptibility was significantly affected when three targeted genes were successfully knocked down. Compared with PRVABC59, infection of Ae. albopictus with FSS13025 generated more 21-nt virus small interference RNA. It can be concluded that the susceptibility of vector Aedes spp. mosquitoes to Zika viruses varies and that the interactions between mosquitoes and Zika virus correlate with susceptibility. © 2020 The Authors. Insect Science published by John Wiley & Sons Australia, Ltd on behalf of Institute of Zoology, Chinese Academy of Sciences.

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