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Survival of Patients with Cystic Fibrosis Depending on Mutation Type and Nutritional Status.

Authors
  • Szwed, A1
  • John, A2
  • Goździk-Spychalska, J3
  • Czaiński, W3
  • Czerniak, W3
  • Ratajczak, J2
  • Batura-Gabryel, H3
  • 1 Department of Human Biological Development, Institute of Anthropology, Faculty of Biology, Adam Mickiewicz University in Poznan, 89 Umultowska Street, 61-614, Poznan, Poland. [email protected] , (Poland)
  • 2 Department of Human Biological Development, Institute of Anthropology, Faculty of Biology, Adam Mickiewicz University in Poznan, 89 Umultowska Street, 61-614, Poznan, Poland. , (Poland)
  • 3 Department of Pulmonology, Allergology and Respiratory Oncology, Poznan University of Medical Sciences, 84 Szamarzewskiego Street, 60-569, Poznan, Poland. , (Poland)
Type
Published Article
Journal
Advances in experimental medicine and biology
Publication Date
Jul 19, 2017
Identifiers
DOI: 10.1007/5584_2017_66
PMID: 28721579
Source
Medline
Keywords
License
Unknown

Abstract

The purpose of the study was to evaluate the influence of nutrition and of the severity of mutation type on survival rate in cystic fibrosis (CF) patients. Data were longitudinally collected from 60 hospitalized adult CF patients, aged 18-50. The variables consisted of body mass index (BMI) ratio, Cole's BMI cut-off points, severity of mutation type, and survival rate of CF patients. We found that the mean BMI was strongly associated with the severity of mutation type and was significantly lower in patients with severe mutations of grade I and II. The mutation type significantly affected the patients' survival rate; survival was greater in patients with mild and undefined mutation types. The BMI and Cole's cut-off points also had a significant influence on survival rate. CF patients, who suffered from malnutrition and emaciation, had a shorter survival rate than those with proper nutritional status. In conclusion, the study findings confirmed a significant effect of nutritional status and of mutation type on survival rate of CF patients.

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