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Surveying the chemical composition and antibacterial activity of essential oils from selected medicinal plants against human pathogens

Authors
  • Osanloo, Mahmoud1, 2
  • Ghaznavi, Ghazal3
  • Abdollahi, Abbas4
  • 1 Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
  • 2 Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran
  • 3 Department of Medical Biotechnology, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran
  • 4 Department of Microbiology, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran
Type
Published Article
Journal
Iranian Journal of Microbiology
Publisher
Tehran University of Medical Sciences
Publication Date
Dec 01, 2020
Volume
12
Issue
6
Pages
577–583
Identifiers
DOI: 10.18502/ijm.v12i6.5032
PMID: 33613912
PMCID: PMC7884278
Source
PubMed Central
Keywords
Disciplines
  • Original Article
License
Unknown

Abstract

Background and Objectives: Essential oils (EOs) with different biological activities, such as antibacterial properties, are a valuable resource for developing new drugs. Materials and Methods: Ingredients of six medicinally important EOs, including Artemisia dracunculus, Anethum graveolens, Citrus limon, Citrus sinensis, Cinnamomum zeylanicum and Zingiber officinale , were identified using GC-MS analysis. Moreover, their five major compounds were also listed. Furthermore, the half-maximal inhibitory concentration (IC50) against four important human bacteria was also investigated using the 96-well plate microdilution. Results: C. sinensis EO with IC50 of 1.0 and 4.7 mg.mL–1 have the most effect on the growth of S. aureus and P. aeruginosa. Moreover, EOs of Cinnamomum zeylanicum (IC50: 1.0 mg. Ml–1) and Artemisia dracunculus (IC50: 1.3 mg.mL–1) significantly showed better inhibitory effect on E. coli and K. pneumoniae. Conclusion: These EOs could be used for developing inexpensive, potent, and green antibacterial agents.

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