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Surveillance moléculaire de la résistance de Plasmodium falciparum aux associations thérapeutiques à base d'artémisinine

Authors
  • Mvumbi Makaba, Dieudonné
  • Bobanga Lengu, Thierry
  • Kayembe Ntumba, Jean-Marie
  • Mvumbi Lelo, Georges
  • Situakibanza Nani-Tuma, Hippolyte
  • Benoit-Vical, Françoise
  • Melin, Pierrette
  • De Mol, Patrick
  • Hayette, Marie-Pierre
Publication Date
Jun 08, 2017
Source
ORBi
Keywords
Language
English
License
Unknown
External links

Abstract

Malaria is a major public health problem in the Democratic Republic of Congo. Despite progress achieved over the past decade in the fight against malaria, further efforts have to be done such as in the surveillance and the containment of Plasmodium falciparum resistant strains. We investigated resistance to artemisinin-based combination therapies currently in use in Democratic Republic of Congo by surveying molecular polymorphisms in three genes: pfcrt, pfmdr1 and pfk13 to explore possible emergence of amodiaquine, lumefantrine or artemisinin resistance in Democratic Republic of Congo. This study essentially revealed that resistance to chloroquine is still decreasing while polymorphism related to amodiaquine resistance seems to be not present in Democratic Republic of Congo, that three samples, located in the east of the country, harbor Pfmdr1 amplification and that none of the mutations found in South-East Asia correlated with artemisinine resistance have been found in Democratic Republic of Congo. But new mutations have been identified, especially the M476K, occurred in the same position that the M476I previously identified in the F32-ART strain, strongly resistant to artemisinine. Antimalarial first-line treatments currently in use in Democratic Republic of Congo are not associated with emergence of molecular markers of resistance.

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