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Surgery in Nasal Polyp Patients: Outcome After a Minimum Observation of 10 Years.

Authors
  • Vlaminck, Stephan1
  • Acke, Frederic2
  • Prokopakis, Emmanuel3
  • Speleman, Kato1
  • Kawauchi, Hideyuki4
  • van Cutsem, Jean-Christophe1
  • Hellings, Peter W5
  • Jorissen, Mark5
  • Seys, Sven5
  • Bachert, Claus2
  • Zele, Thibaut Van2
  • Lambrecht, Bart N6, 7, 8
  • Gevaert, Philippe2
  • 1 Department of Otorhinolaryngology, AZ St-Johns Hospital, Bruges, Belgium. , (Belgium)
  • 2 Department of Otorhinolaryngology, University Hospital, Ghent, Belgium. , (Belgium)
  • 3 Department of Otorhinolaryngology, University of Crete School of Medicine, Crete, Greece. , (Greece)
  • 4 Department of Otorhinolaryngology, University Hospital, Shimane, Japan. , (Japan)
  • 5 Department of Otorhinolaryngology, University Hospital, Leuven, Belgium. , (Belgium)
  • 6 Laboratory of Immunoregulation, VIB Center for Inflammation Research, Ghent, Belgium. , (Belgium)
  • 7 Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium. , (Belgium)
  • 8 Department of Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands. , (Netherlands)
Type
Published Article
Journal
American journal of rhinology & allergy
Publication Date
Jul 01, 2021
Volume
35
Issue
4
Pages
449–457
Identifiers
DOI: 10.1177/1945892420961964
PMID: 33019818
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Chronic rhinosinusitis with nasal polyps (CRSwNP) often requires surgery, but recurrence even after surgery is common. Recurrence rates largely vary in literature and asthma seems to be a comorbid factor. In this study, we aim to estimate disease recurrence during a long-term follow-up, together with the investigation of possible predicting and/or influencing parameters. Out of 196 patients operated for CRSwNP between 01/2000 and 01/2006, 133 patients had a follow-up of at least 10 years and could be included. The inflammatory profile at surgery was determined on nasal tissue and sinonasal secretions, and included analysis of eosinophils, eosinophilic-rich mucus (ERM) typically containing Charcot-Leyden crystals (CLC), and fungal hyphae (FH). During follow-up, recurrence, received treatments and comorbidities were collected. Out of the 133 included patients, local eosinophilia was present in 81% and ERM in 60%. Recurrence during follow-up was observed in 62%, and was associated with local eosinophilia and ERM (both p < 0.001). Asthma was present in 28% at inclusion, and 17% developed asthma after surgery during follow-up. The presence of asthma, at inclusion as well as developed during follow-up, was significantly associated with recurrence of CRSwNP (p = 0.001 for group comparison). Recurrence after CRSwNP surgery is common when a long-term follow-up is taken into account. ERM detected in sinonasal secretions at surgery seems to be a predictive factor for recurrence and need for revision surgery. Asthma is a frequently found comorbid factor in CRSwNP, develops even at higher age despite surgical treatment for CRSwNP, and is also associated with a higher recurrence rate. Sustained medical care after surgery is mandatory.

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