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Surgery and hematogenous dissemination: comparison between the detection of circulating tumor cells and of tumor DNA in plasma before and after tumor resection in rats.

Authors
  • García-Olmo, Dolores C
  • Gutiérrez-González, Lydia
  • Samos, Julia
  • Picazo, María G
  • Atiénzar, Manuel
  • García-Olmo, Damián
Type
Published Article
Journal
Annals of surgical oncology
Publication Date
Aug 01, 2006
Volume
13
Issue
8
Pages
1136–1144
Identifiers
PMID: 16865589
Source
Medline
License
Unknown

Abstract

In our animal model, the hematogenous dissemination of tumors due to surgery seemed to be more closely related to tumor-derived cell-free DNA than to circulating tumor cells. In addition, the surgical resection of primary tumors did not inhibit the development of metastases.

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