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Surfactant-associated proteins: structure, function and clinical implications.

Authors
  • Ketko, Anastasia K
  • Donn, Steven M
Type
Published Article
Journal
Current pediatric reviews
Publication Date
Jan 01, 2014
Volume
10
Issue
2
Pages
162–167
Identifiers
PMID: 25088270
Source
Medline
License
Unknown

Abstract

Surfactant replacement therapy is now the standard of care for infants with respiratory distress syndrome. As the understanding of surfactant structure and function has evolved, surfactant-associated proteins are now understood to be essential components of pulmonary surfactant. Their structural and functional diversity detail the complexity of their contributions to normal pulmonary physiology, and deficiency states result in significant pathology. Engineering synthetic surfactant protein constructs has been a major research focus for replacement therapies. This review highlights what is known about surfactant proteins and how this knowledge is pivotal for future advancements in treating respiratory distress syndrome as well as other pulmonary diseases characterized by surfactant deficiency or inactivation.

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