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A surface-charge study on cellular-uptake behavior of F3-peptide-conjugated iron oxide nanoparticles.

Authors
Type
Published Article
Journal
Small
Publisher
Wiley (John Wiley & Sons)
Volume
5
Issue
17
Pages
1990–1996
Identifiers
DOI: 10.1002/smll.200900520
Source
Ruoslahti Lab
License
Unknown

Abstract

Surface-charge measurements of mammalian cells in terms of Zeta potential are demonstrated as a useful biological characteristic in identifying cellular interactions with specific nanomaterials. A theoretical model of the changes in Zeta potential of cells after incubation with nanoparticles is established to predict the possible patterns of Zeta-potential change to reveal the binding and internalization effects. The experimental results show a distinct pattern of Zeta-potential change that allows the discrimination of human normal breast epithelial cells (MCF-10A) from human cancer breast epithelial cells (MCF-7) when the cells are incubated with dextran coated iron oxide nanoparticles that contain tumor-homing F3 peptides, where the tumor-homing F3 peptide specifically bound to nucleolin receptors that are overexpressed in cancer breast cells.

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