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Surface-based laminar analysis of diffusion abnormalities in cortical and white matter layers in neocortical epilepsy.

Authors
  • Govindan, Rajkumar Munian
  • Asano, Eishi
  • Juhasz, Csaba
  • Jeong, Jeong-Won
  • Chugani, Harry T
Type
Published Article
Journal
Epilepsia
Publication Date
Apr 01, 2013
Volume
54
Issue
4
Pages
667–677
Identifiers
DOI: 10.1111/epi.12129
PMID: 23448199
Source
Medline
License
Unknown

Abstract

Our results suggest specific patterns of diffusion changes in the cortical fractions and the underlying white matter of the epileptic region compared to electrographically normal and normal control regions. The abnormal increase in diffusivity of the superficial cortex might be associated with microstructural abnormalities commonly seen in layers II through IV of epileptic cortex. Such combined use of a high-resolution structural image to extract the laminar diffusion values, which are highly sensitive to microstructural alterations, could be of clinical value in localizing epileptogenic cortex.

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