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Suramin-sensitive suppression of paired-pulse inhibition by adenine nucleotides in rat hippocampal slices.

Authors
  • Nikbakht, M R
  • Stone, T W
Type
Published Article
Journal
Neuroscience Letters
Publisher
Elsevier
Publication Date
Jan 07, 2000
Volume
278
Issue
1-2
Pages
45–48
Identifiers
PMID: 10643797
Source
Medline
License
Unknown

Abstract

In order to assess the possible presence of presynaptic P2 receptors for nucleotides in the hippocampus, adenosine triphosphate and betagamma-methyleneATP have been examined on paired-pulse inhibition in rat hippocampal slices. Both compounds reproduced the effects of adenosine and reduced the amount of paired-pulse inhibition at an interpulse interval of 10 ms and increased the amount of facilitation at intervals of 20 and 50 ms. These effects were prevented by 8-phenyltheophylline and adenosine deaminase, indicating their mediation by adenosine. The effects were also reduced by suramin at 50 microM, suggesting the possible activation of P2 receptors. It is suggested that a population of P2 receptors may exist which promote the release of endogenous adenosine in the hippocampus.

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