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Supragastric belching in Japan: lower prevalence and relevance for management of gastroesophageal reflux disease compared to United Kingdom

Authors
  • Sawada, Akinari1, 2
  • Itami, Hideaki3
  • Nakagawa, Kenichiro3
  • Hirano, Shinji2
  • Kitamura, Hiroyuki2
  • Nakata, Rieko2
  • Takashima, Shingo2
  • Abe, Yasuaki3
  • Saito, Masahiro3
  • Yazaki, Etsuro1
  • Kawamura, Osamu4
  • Tanaka, Fumio2
  • Takeuchi, Toshihisa5
  • Koike, Tomoyuki3
  • Masamune, Atsushi3
  • Fujiwara, Yasuhiro2
  • Higuchi, Kazuhide5
  • Sifrim, Daniel1
  • 1 Queen Mary University of London,
  • 2 Osaka City University Graduate School of Medicine,
  • 3 Tohoku University Graduate School of Medicine,
  • 4 Department of Gastroenterology, Kamimoku SPA Hospital, Minakami, Japan
  • 5 Osaka Medical College,
Type
Published Article
Journal
Journal of Gastroenterology
Publisher
Springer Singapore
Publication Date
Aug 24, 2020
Volume
55
Issue
11
Pages
1046–1053
Identifiers
DOI: 10.1007/s00535-020-01720-9
PMID: 32839926
PMCID: PMC7567718
Source
PubMed Central
Keywords
License
Unknown

Abstract

Background Supragastric belching (SGB) may play a role in the pathophysiology of proton pump inhibitors (PPIs)-refractoriness in gastroesophageal reflux disease (GERD). SGB may be present in up to 40% of reflux symptoms in PPI-refractory GERD. Most reports on SGB have come from Western countries, and little is known about the prevalence and relevance of SGB in Asian refractory GERD patients. This study aimed at comparing the role of SGB in GERD patients in Japan and the UK. Methods We re-analyzed impedance-pH monitoring tracings from patients who were referred to tertiary centers in Japan and the UK due to PPI-refractory reflux symptoms. The prevalence of excessive SGB and the impact of SGB on reflux symptoms were compared between the two countries. Results Impedance-pH tracings from124 Japanese and 83 British patients were re-analyzed. Japanese patients were significantly younger and had smaller body mass index than the British ( P < 0.001). Japanese patients had significantly lower prevalence of excessive SGB (18.5%) than the UK (36.1%) irrespective of reflux phenotype ( P = 0.006). Logistic regression analysis showed that the geographical/cultural difference was the only factor associated with the different prevalence of SGB (odds ratio; 2.91, 95% CI 1.09–7.73, P = 0.032). SGB were related to typical reflux symptoms very rarely in Japan [0% (0–4.9)] compared to the UK [35% (0–54.1)] ( P = 0.071). Conclusions The prevalence of SGB and their impact on reflux symptoms is significantly lower in Japan compared to the UK. The difference is not related to reflux parameters but might come from ethnic/cultural factors to be further characterized.

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