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Suppressor T-lymphocyte activity in wheezy children with and without treatment by hyposensitization.

Authors
  • Rivlin, J
  • Kuperman, O
  • Freier, S
  • Godfrey, S
Type
Published Article
Journal
Clinical allergy
Publication Date
Jul 01, 1981
Volume
11
Issue
4
Pages
353–356
Identifiers
PMID: 6457703
Source
Medline
License
Unknown

Abstract

The suppressor cell activity of peripheral blood lymphocytes was investigated in wheezy children by determining the ability of concanavalin A induced suppressor cells to inhibit a mitogen provoked proliferative response. The activity was compared with that of eighteen healthy controls. Of ten infants aged from 5 months to 4 1/2 years, with recurrent wheezy bronchitis, three had much reduced suppressor cell activity (2 s.d. or more below that of controls). Of twelve asthmatic children aged from 4 1/2 to 12 years, seven had much reduced suppressor cell activity. The remaining five asthmatic children with normal suppressor cell activity had all received hyposensitization therapy. We speculate that immune hyposensitization therapy might act by stimulating lymphocyte suppressor activity.

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