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Suppressive mechanisms by Heligmosomoides polygyrus-induced Tregs in C57BL/6 mice change over time and differ to that of naïve mice.

Authors
  • Bowron, Joel1
  • Ariyaratne, Anupama1
  • Luzzi, Mayara de Cassia1
  • Szabo, Edina1
  • Finney, Constance A M1
  • 1 Faculty of Science, Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada. , (Canada)
Type
Published Article
Journal
European Journal of Immunology
Publisher
Wiley (John Wiley & Sons)
Publication Date
Aug 01, 2020
Volume
50
Issue
8
Pages
1167–1173
Identifiers
DOI: 10.1002/eji.201948392
PMID: 32311083
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Disrupting or harnessing immune suppression is leading to new therapeutic avenues in a number of immune-related diseases. Understanding the suppressive functions of regulatory T cells (Tregs) in different environments is therefore key. Parasitic worms are strong inducers of Tregs and previous research has suggested that parasite-induced Tregs are stronger suppressors than naïve Tregs. In strains susceptible to the intestinal worm Heligmosomoides polygyrus, like C57BL/6 mice, it has been hypothesized that increased Treg suppression downregulates both Th1 and Th2 responses, leading to chronic infections and high worm burden. Here, we show that the suppressive capacity of Tregs is no different between cells from infected and/or naive animals. In vitro suppression induced by CD4+ CD25+ Tregs (Peyers' Patches or the mesenteric lymph nodes), isolated early (day 7, tissue dwelling phase) or late (day 21, luminal phase) during infection was similar to that induced by cells from naïve animals. Suppression was CTLA-4 dependent in Tregs from acute but not chronic infection or in Tregs from naïve animals. This highlights the versatility of Tregs and the importance of extensive Treg characterization prior to potential in vivo manipulation of this cell type. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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