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Suppression of mitogen responses and graft-versus-host reaction by splenocytes from mice bearing Lewis lung carcinoma.

Authors
  • Anaclerio, A
  • Moras, M L
  • Conti, G
  • Mistrello, G
  • Spreafico, F
Type
Published Article
Journal
Journal of the National Cancer Institute
Publication Date
Aug 01, 1978
Volume
61
Issue
2
Pages
471–475
Identifiers
PMID: 28421
Source
Medline
License
Unknown

Abstract

The presence of suppressor cells in the spleens of C57BL/6 mice bearing Lewis lung carcinoma was investigated with the use of the in vitro lymphoproliferative response to mitogens and the graft-versus-host reaction (GVHR) as test systems. Splenocytes from tumor-bearing mice showed a lower response to mitogens when obtained 15-27 days after tumor transplant. In parallel, these cells were capable of suppressing the response of normal spleen cells to mitogens and their capacity to mount a GVHR in allogeneic hosts. Treatments with procedures known to remove adherent phagocytes, but not treatments with anti-Thy 1.2 serum plus complement, removed the suppressive activity observed.

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