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Suppression by gamma-hydroxybutyric acid of ethanol withdrawal syndrome in rats.

Authors
  • Fadda, F
  • Colombo, G
  • Mosca, E
  • Gessa, G L
Type
Published Article
Journal
Alcohol and alcoholism (Oxford, Oxfordshire)
Publication Date
Jan 01, 1989
Volume
24
Issue
5
Pages
447–451
Identifiers
PMID: 2818752
Source
Medline
License
Unknown

Abstract

The ability of gamma-hydroxybutyric acid to suppress ethanol withdrawal syndrome was tested in male rats rendered physically dependent on ethanol by several intragastric administrations of ethanol (9-15 g/kg daily for 7 days). Gamma-hydroxybutyrate (0.25, 0.50 and 1.00 g/kg i.p.), administered 8 hr after the last ethanol dose, produced a dose-dependent inhibition of withdrawal signs such as tremors and audiogenically-induced seizures; the highest dose tested suppressed all ethanol withdrawal symptoms.

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