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Suppressed Gastric Mucosal TGF-beta1 Increases Susceptibility to H. pylori-Induced Gastric Inflammation and Ulceration: A Stupid Host Defense Response.

Authors
  • Jo, Yunjeong1
  • Han, Sang Uk
  • Kim, Yoon Jae
  • Kim, Ju Hyeon
  • Kim, Shin Tae
  • Kim, Seong-Jin
  • Hahm, Ki-Baik
  • 1 Laboratory of Cell Regulation and Carcinogenesis, Lee Gil Ya Cancer and Diabetes Institute, Gachon University of Medicine and Science, Incheon, Korea. , (North Korea)
Type
Published Article
Journal
Gut and liver
Publication Date
Mar 01, 2010
Volume
4
Issue
1
Pages
43–53
Identifiers
DOI: 10.5009/gnl.2010.4.1.43
PMID: 20479912
Source
Medline
Keywords
License
Unknown

Abstract

H. pylori infection was associated with depressed gastric mucosal TGF-beta1 for up to 24 hr, but this apparent strategy for rescuing cells from H. pylori attachment exacerbated the gastric inflammation.

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