The development of coronary interventional strategies and devices has provided an alternative to surgery for coronary artery disease. The femoral artery is the most common access site for therapeutic cardiac interventions. The methods to achieve hemostasis post procedure vary from conventional, where the arterial puncture site is externally compressed, to novel, where the femoral artery is sealed with a device. One such device is a suture mediated percutaneous vascular closure system developed by Perclose, Incorporated. It provides a safe, effective method to achieve immediate hemostasis of the femoral artery. The vascular complication rate is only 0.78%, time to hemostasis is within 1.3 minutes, and time to ambulation in within 5.5 minutes. These advantages provide improved patient comfort and have a positive economic impact.