Phytase is the most common enzyme used in broiler diet mainly to improve phosphorus (P) digestibility and reduce P excretion to environment, but its effectiveness together with other enzymes such as xylanase, amylase and protease (XAP) is not widely evaluated. Current study was conducted to evaluate the efficacy of Buttiauxella spp. phytase supplementation at 1000 FTU/kg alone and its combination with XAP (2000 U/kg xylanase, 200 U/kg amylase and 4000 U/kg protease) on broiler performance and bone mineralization. A total 2849 male broilers Lohmann Indian River (LIR) were randomly assigned to 7 treatments with 11 replications. Treatments were positive control (PC) using standard diet followed LIR recommendation, negative control 1 (NC1) with nutrient reduction of 0.19% units available P, 0.2% units calcium (Ca), 0.41% units crude protein (CP) and 69 kcal/kg AME, NC2 applied similar reduction except for AME which was 105 kcal/kg, and on top of NCs was phytase and/or XAP supplementation. NC1 and NC2 significantly (P<0.05) reduced body weight, mortality-corrected feed conversion ratio (McFCR) and toe ash percentage compared to PC. Phytase alone on top of NCs significantly (P<0.05) improved body weight, McFCR and toe ash percentage. Further, combination of phytase with XAP numerically showed better weight gain, McFCR and broiler index (BI). These data suggest phytase and/or XAP supplementation is effective to maintain broiler performance and toe ash under nutrient deficiency, this because enzymes able to reduce the anti-nutritional effect and lead to better nutrient digestibility.