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Supplementation of omega 3 fatty acids may improve hyperactivity, lethargy, and stereotypy in children with autism spectrum disorders: a meta-analysis of randomized controlled trials.

Authors
  • Cheng, Yu-Shian1
  • Tseng, Ping-Tao1, 2
  • Chen, Yen-Wen3
  • Stubbs, Brendon4, 5, 6
  • Yang, Wei-Chieh7
  • Chen, Tien-Yu8, 9
  • Wu, Ching-Kuan1
  • Lin, Pao-Yen10, 11
  • 1 Department of Psychiatry, Tsyr-Huey Mental Hospital, Kaohsiung Jen-Ai's Home.
  • 2 WinShine Clinics in Specialty of Psychiatry.
  • 3 Prospect Clinic for Otorhinolaryngology & Neurology, Kaohsiung, Taiwan, Republic of China. , (China)
  • 4 Physiotherapy Department, South London and Maudsley NHS Foundation Trust.
  • 5 Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London.
  • 6 Faculty of Health, Social Care and Education, Anglia Ruskin University, Chelmsford, UK.
  • 7 Department of Pediatrics, DA-AN Women and Children Hospital, Tainan.
  • 8 Department of Psychiatry, Tri-Service General Hospital, Taipei.
  • 9 School of Medicine, National Defense Medical Center, Taipei.
  • 10 Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine.
  • 11 Institute for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, Republic of China. , (China)
Type
Published Article
Journal
Neuropsychiatric Disease and Treatment
Publisher
Dove Medical Press
Publication Date
Jan 01, 2017
Volume
13
Pages
2531–2543
Identifiers
DOI: 10.2147/NDT.S147305
PMID: 29042783
Source
Medline
Keywords
License
Unknown

Abstract

Six trials were included (n=194). Meta-analysis showed that supplementation of omega 3 fatty acids improved hyperactivity (difference in means =-2.692, 95% confidence interval [CI] =-5.364 to -0.020, P=0.048, studies =4, n=109), lethargy (difference in means =-1.969, 95% CI =-3.566 to -0.372, P=0.016, studies =4, n=109), and stereotypy (difference in means =-1.071, 95% CI =-2.114 to -0.029, P=0.044, studies =4, n=109). No significant differences emerged between supplementation of omega 3 fatty acids and placebo in global assessment of functioning (n=169) or social responsiveness (n=97). Our preliminary meta-analysis suggests that supplementation of omega 3 fatty acids may improve hyperactivity, lethargy, and stereotypy in ASD patients. However, the number of studies was limited and the overall effects were small, precluding definitive conclusions. Future large-scale randomized clinical trials are needed to confirm or refute our findings.

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