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Supplemental Parenteral Vitamin E Into Conventional Soybean Lipid Emulsion Does Not Prevent Parenteral Nutrition-Associated Liver Disease in Full-Term Neonatal Piglets.

Authors
  • Muto, Mitsuru1
  • Lim, David2
  • Soukvilay, Amanda1
  • Field, Catherine3
  • Wizzard, Pamela R1
  • Goruk, Susan3
  • Ball, Ronald O3
  • Pencharz, Paul B4, 5
  • Mi, Si3
  • Curtis, Jonathan3
  • Wales, Paul W1, 5, 6
  • Turner, Justine M1, 2
  • 1 1 Department of Pediatrics, University of Alberta, Canada.
  • 2 2 Department of Surgery, University of Alberta, Canada.
  • 3 3 Department of Agricultural Food and Nutritional Science, University of Alberta, Canada.
  • 4 4 Department of Gastroenterology and Nutrition, Hospital for Sick Children, Toronto, Ontario, Canada.
  • 5 5 Group for Improvement of Intestinal Function and Treatment, Hospital for Sick Children, Toronto, Ontario, Canada.
  • 6 6 Division of General Surgery, Hospital for Sick Children, Toronto, Ontario, Canada.
Type
Published Article
Journal
JPEN. Journal of parenteral and enteral nutrition
Publication Date
May 2017
Volume
41
Issue
4
Pages
575–582
Identifiers
DOI: 10.1177/0148607115612030
PMID: 26471989
Source
Medline
Keywords
License
Unknown

Abstract

In term neonatal piglets, supplemental vitamin E did not prevent cholestasis. Additional vitamin E was not associated with reduced inflammation or oxidative stress. The benefit of supplementing vitamin E into conventional lipid, vs adding fish oil, to prevent early onset of PNALD requires further clarification.

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