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Superresolution three-dimensional images of fluorescence in cells with minimal light exposure.

Authors
  • 1
Type
Published Article
Journal
Science (New York, N.Y.)
Publication Date
Volume
268
Issue
5216
Pages
1483–1487
Identifiers
PMID: 7770772
Source
Medline

Abstract

Fluorescent probes offer insight into the highly localized and rapid molecular events that underlie cell function. However, methods are required that can efficiently transform the limited signals from such probes into high-resolution images. An algorithm has now been developed that produces highly accurate images of fluorescent probe distribution inside cells with minimal light exposure and a conventional light microscope. This method provides resolution nearly four times greater than that currently available from any fluorescence microscope and was used to study several biological problems.

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