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Supernatant virus release as a differentiating marker between low passage and vaccine strains of human cytomegalovirus.

Authors
  • Yamane, Y
  • Furukawa, T
  • Plotkin, S A
Type
Published Article
Journal
Vaccine
Publisher
Elsevier
Publication Date
Dec 01, 1983
Volume
1
Issue
1
Pages
23–25
Identifiers
PMID: 6099639
Source
Medline
License
Unknown

Abstract

The ratio of CMV virus released into the supernatant per infected human fibroblast was studied for three laboratory strains and seven fresh isolates. The former all gave ratios over one whereas the latter gave ratios less than one. This phenomenon may serve as a marker of high passage attenuated virus, as about 25 passages were required in case of one strain to change this property.

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